Il 12 Family Signaling Pathways R D Systems
The signaling pathway that mediates the TLR2 stimulated production of IL17 and IL23 was investigated by using treatment with specific signaling inhibitors We showed that TLR2, TLR4, TLR6, IL17 and the cytokines associated with Th17 cells were highly expressed in salivary glands of pSS patients but not in controlsImportant as IL23 for Th17's differentiation and function, STAT3 phosphorylated by IL23 signal can not only promote the expression of RORc, acting on differentiation of Th17, but bind to IL17's promoter, being a direct regulator of IL17 That's to say, high serum IL23 level and its active JAK2/STAT3 signal pathway play a critical role in resulting in high serum IL17 level and high
